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Molecular and Genetic Medicine

ISSN: 1747-0862

Open Access

Srinivasa T. Reddy

Department of Medicine, and Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA

Publications
  • Review   
    Ramatroban as a Novel Immunotherapy for COVID-19
    Author(s): Ajay Gupta*, Kamyar Kalantar-Zadeh and Srinivasa T. Reddy

    SARS-CoV-2 virus suppresses host innate and adaptive immune responses, thereby allowing the virus to proliferate, and cause multiorgan failure, especially in the elderly. Respiratory viruses stimulate cyclooxygenase-2 (COX-2) to generate prostanoids including Prostaglandin D2 (PGD2) and thromboxane A2. Furthermore, PGD2 concentrations in the airways increase with aging. PGD2 action mediated via DP2 receptors suppresses both innate and adaptive immune responses, by inhibiting interferon-λ and stimulation of myeloid monocyte-derived suppressor cells respectively. PGD2 and thromboxane A2 actions via the TP receptors activate platelets leading to a prothrombotic state. Ramatroban, a small-molecule antagonist of DP2 and TP receptors, reverses viremia-associated proinflammatory, immunos.. Read More»
    DOI: 10.37421/jmgm.2020.14.457

    Abstract HTML PDF

Recommended Conferences

STEM CELL & REGENERATIVE MEDICINE

San Francisco, USA

World Biotechlogy Congress 2020

Barcelona, Spain
 

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