Molecular and Genetic Medicine

Department of Science, University Of New South Wales, Sydney NSW 2052, Australia

Publications

• Mini Review   
  Genetic Modifiers in Complex Diseases: Understanding their Role in Disease Pathogenesis and Treatment
  Author(s): Muriel Hitzler*
  
  Complex diseases, characterized by multifactorial inheritance patterns, are influenced by a combination of genetic and environmental factors. Genetic modifiers, secondary genetic variations that interact with primary disease-causing mutations, play a pivotal role in shaping the clinical manifestations and outcomes of complex diseases. This research article explores the concept of genetic modifiers, their mechanisms of action, and their implications in disease pathogenesis and treatment strategies. We delve into case studies across diverse disease domains, including cystic fibrosis, cardiovascular disorders, and neurodegenerative diseases, to elucidate how genetic modifiers contribute to phenotypic variability, disease severity, and response to therapeutic interventions. Additionally, we discuss emerging research methodologies, such as genome-wide association st.. Read More»
  DOI: 10.37421/1747-0862.2023.17.619

  Abstract HTML PDF