Journal of Cytology & Histology

ISSN: 2157-7099

Open Access

Mohd I. Lone

Department of Pathology, Sher-E-Kashmir Institute of Medical Sciences Soura Srinagar, Jammu and Kashmir, India

  • Research Article   
    Immunohistochemistry of Germ Cell Tumors at Various Anatomic Sites
    Author(s): Manal Abdul Lateef*, Mohd I. Lone and Shuaeb Bhat

    Background: The usefulness of IHC markers in the differential diagnosis of germ cell tumors has been recognized for decades. Germ cell neoplasms can show a bewildering array of appearances, and there may be significant morphologic overlap among subtypes. For this reason, Immuno-histochemistry is often performed to assist in accurately assessing the types and extent of germ cell elements present within a tumor. The different IHC markers used in this study included include a) alpha - fetoprotein (AFP), b) the beta subunit of human chorionic gonadotropin c) cytokeratin, d) S-100 protein e) CD30 f) GFAP. g) CD117 h) PLAP. The main objectives of the study were to observe the IHC staining patterns of both gonadal and extragonadal GCTs. Methods: The study was conducted for a period of 5 years from 2015 to 2019 and was an observational study. The re.. Read More»
    DOI: 10.37421/2157-7099.2022.13.646

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