GET THE APP

..

Virology: Current Research

Open Access

Mohamed Gomaa Seadawy

Main Laboratories, Chemical Warfare, Egyptian Army Forces, Cairo, Egypt

Publications
  • Research Article   
    In silico Docking for Inhibition Neuropilin-1 (Sars-Cov-2 Receptor) by Some Natural Compound and Approved Drugs
    Author(s): Mohamed Gomaa Seadawy*, Mohamed Shamel Eldesoky, Aya Ahmed and Abdel Rahman Nabwi Zekri

    Background: Neuropilin-1 (NRP-1) is a multifunctional transmembrane receptor for ligands that affect developmental axonal growth and angiogenesis. Beside its role in cancer, NRP-1 is a reported entrance for several viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of coronavirus disease 2019 (COVID-19). Methods: We made Insilco docking between the spike protein and Neuropilin-1 using Cluspro 2.0 software. Therefore, Neuropilin-1 becomes host factor for SARSCoV- 2 infection. Then by using molecular docking, we test nine compounds against Neuropilin-1 for its inhibition. Results and Conclusion: Our study revealed that some drugs and natural compounds success in inhibition of binding between the virus and its new receptor with Insilco docking data... Read More»

    Abstract PDF

tempobet

tempobet giriş

tempobet giriş

süperbetin

tipobet yeni giriş adresi tipobet e yeni giriş tipobet güncel giriş adresi imajbet giriş adresi

mobilbahis giriş

arrow_upward arrow_upward