Journal of Brain Research

Department of Biology and Neuroscience Program, Agnes Scott College, Decatur, Georgia, USA

Publications

• Research   
  Endosomal Trafficking is disrupted in Neurodevelopmental Disorders
  Author(s): Susan Cordero Romero, Ruvimbo Dzvurumi, Alexia Crockett, Alexandra Lombardo, Jhodi Webster, Samantha Hatcher, Alix Wagner, Diana Ghebrezadik, Asiya Abawari, Camryn Smith, Lauren Neal, Yommi Tadesse, Molly Beauchamp, Stacey B.B. Dutton and Jennifer L. Larimore*
  
  Endosomal trafficking has been implicated in several neurodevelopmental disorders including Rett Syndrome (RTT) and Schizophrenia (SZ). Endosomal proteins have been identified in genomic studies in both disorders, suggesting a common molecular mechanism. To characterize endosomal proteins in these disorders, we analyzed protein expression in the cortex and dentate gyrus of the hippocampus as well as in synaptosome preparations from whole-brain lysates. Immunofluorescent staining demonstrated alterations in key endosomal proteins in coronal brain sections from Mecp2 deficient mice and BLOC-1 deficient mice in the cortex and hippocampus. In addition, biochemical analysis of whole-brain homogenate and synaptosome fractions demonstrated an alteration in endosomal markers. Neurite outgrowth was also significantly decreased in PC12 cells lacking dysbindin and Mecp2. Lastly, to .. Read More»
  DOI: 10.37421/2684-4583.2021.4.121

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