Cancer Science & Therapy

Department of Oncologist, Breast Disease Center (Centro de Doenças da Mama – CDM) and Nossa Senhora das Graças Hospital, Curitiba, Paraná, Brazil

Publications

• Research Article   
  Comparison between Ki67 Expression and Oncotype Dx® Recurrence Score in Luminal Breast Carcinomas
  Author(s): Ana Helena Willrich Rasera*, Cleverton Spautz, Iris Rabinovich, Ana Cléa Andrade, Cícero Urban, Karina Furlan Anselmi and Ana Paula Martins Sebastião
  
  Introduction: In early-stage breast cancer, there is a constant search to identify which patients will benefit from chemotherapy. Among the most widely used genetic tests is Oncotype DX®, a validated prognostic marker. However, its high cost is still a major limitation. As a more financially viable alternative, the cell proliferation index determined by the Ki67 antigen is used. Objective: To evaluate the percentage of Ki67 expression and its relationship with the Oncotype DX® recurrence score in luminal breast carcinomas. Methods: 79 Oncotype DX® results available in the last 5 years were analyzed and compared with the respective anatomopathological and immunohistochemical reports. Results: The mean age was 56 years with tumors ≤ 2 cm (72.2%), with a predominance of carcinomas of no special type (73.. Read More»
  

  Abstract PDF