Journal of Clinical Case Reports

Wei Fang

Publications

• Case Report
  Rbap48 Could Act as a Candidate Biological Predictor for the Cognition Impairments of Patients with Temporal Lobe Epilepsy: A Hypothesis Based on Recent Molecular Findings
  Author(s): Ye Tao, Zhongjun Yan, Ce Liu, Jianjie Ma, Wei Wei Xu, Qinghua Yang, Wei Fang and Yifei HuangYe Tao, Zhongjun Yan, Ce Liu, Jianjie Ma, Wei Wei Xu, Qinghua Yang, Wei Fang and Yifei Huang
  
  The temporal lobe epilepsy (TLE) is characterized by the neurodegeneration, abnormal reorganization of circuitry, and the loss of functional inhibition in hippocampus regions. Particularly, the declined neurogenesis in hippocampus has emerged as a significant hallmark of TLE. RbAp48, which is initially recognized as a retinoblastoma binding protein, is also identified as a positive regulator of human neurogenesis owing to its ability to regulate the expression of the pluripotency, differentiation, and cell cycle genes in human PSCs. The deficiency of RbAp48 critically contributes to the dentate gyrus (DG) dysfunction and is closely related to age-related memory deficits. Nevertheless, the roles of RbAp48 in the neurogenesis deterioration and memory loss of TLE patients remain to be determined. In view of the linkage between the deficiency of RbAp48 and the TLE-related memory loss, it .. Read More»
  DOI: 10.4172/2165-7920.1000970

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