Journal of Clinical Case Reports

ISSN: 2165-7920

Open Access

Toshihiro Tajima

N15, W7, Sapporo

  • Case Report
    A Patient with Septo-Optic Dysplasia Accompanying with Central Precocious Puberty
    Author(s): Shuntaro Morikawa and Toshihiro TajimaShuntaro Morikawa and Toshihiro Tajima

    Septo-Optic Dysplasia (SOD) is a heterogeneous condition defined by any combination of i) optic nerve hypoplasia, ii) hypopituitarism, and iii) midline brain anomalies such as agenesis of the corpus callosum and absence of the septum pellucidum. We encountered a Japanese girl with optic nerve hypoplasia, growth failure, precocious puberty, and mild developmental delay. Her optic nerve hypoplasia was diagnosed at 4 months of age. Thereafter, she showed growth failure from infancy. Gradual breast development was noticed from 6 years of age. Therefore, she was referred to us at 9.2 years of age. Endocrinological investigations demonstrated deficiencies in growth hormone, adrenocorticotropic hormone, and cortisol. However, serum levels of luteinizing hormone, follicle stimulating hormone, and estradiol were increased to pubertal levels. B.. Read More»
    DOI: 10.4172/2165-7920.1000587

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