Cancer Science & Therapy

ISSN: 1948-5956

Open Access

Thu Annelise Nguyen

K244 Mosier Hall, 1800 Denison Avenue, Manhattan, KS 66506

  • Research Article
    Gap Junction Enhancer Potentiates Cytotoxicity of Cisplatin in Breast Cancer Cells
    Author(s): Ying Ding and Thu Annelise NguyenYing Ding and Thu Annelise Nguyen

    Cisplatin is one of the most widely used anti-cancer drugs due to its ability to damage DNA and induce apoptosis. However, increasing reports of side effects and drug resistance indicate the limitation of cisplatin in cancer therapeutics. Recent studies showed that inhibition of gap junctions diminishes the cytotoxic effect and contributes to drug resistance. Therefore, identification of molecules that counteract gap junctional inhibition without decreasing the anti-cancer effect of cisplatin could be used in combinational treatment, potentiating cisplatin efficacy and preventing resistance. This study investigates the effects of combinational treatment of cisplatin and PQ1, a gap junction enhancer, in T47D breast cancer cells. Our results showed that combinational treatment of PQ1 and .. Read More»
    DOI: 10.4172/1948-5956.1000170

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