Cancer Science & Therapy

ISSN: 1948-5956

Open Access

Pérez-Segura P

Hospital Clínico San Carlos,

  • Review Article
    Chemoprevention in Sporadic Colorectal Cancer: The Role of Salycilates,Nsaids and Coxibs
    Author(s): Manzano A and Pérez-Segura PManzano A and Pérez-Segura P

    Sporadic colorectal cancer (CRC) represents 75% of the total of the CRC cases diagnosed and is the second leading cause of cancer death with a a 5-year survival rate of 62%. The development of colorectal cancer is a complex process involving multiple molecular pathways, since the formation of adenomas to the development of carcinoma in the digestive tract (the so-called “adenoma-carcinoma sequence”), in a process that can last several decades. Thus adenomas are considered a surrogate variable for the development of CRC in clinical trials. Although screening strategies (blood in stool, endoscopic and CT-colonoscopy) have supposed a great advance in the early detection of these tumours, they are associated with inconveniences such as their cost and associated morbidity. Moreover screening does not necessarily prevent the development of cancer or prevent mortality. Therefore,.. Read More»
    DOI: 10.4172/1948-5956.S3-005

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