Molecular and Genetic Medicine

Patricio Gariglio

Biography

 Patricio Gariglio Vidal is currently working in University of California. USA. He is a Doctor of Science 1973. Patricio Gariglio Vidal research interests reflect wide range of publications in various national and international journals.  

Research Interest

Patricio Gariglio Vidal research interest focused on regulation of transcription of eukaryotic genes. Study of the expression of oncogenes (myc, ras) and anti-oncogenes (p53, Rb, TGFbeta) cellular. Epigenetic regulation of the expression of tumor suppressor genes (RARbeta, SLC5A8).Involvement of human papillomavirus (HPV) and its E6 / E7 oncogenes in cervico-uterine cancer (CaCu). Importance of 17beta-estradiol and retinoids in cancer. Model systems to study the possible protective effect of RARbeta (KO mice) on the development of CaCu. Molecular diagnosis of cancers of high incidence in Mexico. Expression of microRNAs as markers for the early diagnosis and prognosis of cervical cancer. Mechanisms of action of resveratrol in proliferation and apoptosis in cell lines. Reactivation of the mutant p53 protein by resveratrol. Genomics and proteomics in model (transgenic mice) cancer systems. Role of E6 and E7 oncoproteins at intercellular junctions and invasive cancer.