Malaria Control & Elimination

ISSN: 2470-6965

Open Access

Palatip Chutoam


  • Research Article
    Effect of Crude Leaf Extract of Bauhinia strychnifolia in BALB/c Mice Infected with Plasmodium berghei
    Author(s): Palatip Chutoam, Suwit Klongthalay and Voravuth SomsakPalatip Chutoam, Suwit Klongthalay and Voravuth Somsak

    Continuous emergence of antimalarial drug resistant malaria parasites and their rapid spread across the globe warrant urgent search for new antimalarials. Traditional medicinal plants have been the main sources for screening active phytochemicals against malaria. Accordingly, this study was aimed at evaluating the antimalarial activity of crude leaf extract of Bauhinia strychnifolia against Plasmodium berghei infected mice. Aqueous crude leaf extract of B. strychnifolia have been prepared and tested for acute toxicity and antimalarial efficacy in P. berghei ANKA infected BALB/c mice. At three oral doses of 100, 500 and 1,000 mg/kg of extract were safe, chemosuppressive and thus prevented body weight loss, packed cell volume reduction and increased mice mean survival time in a dosedependent manner compared to the untreated control group. The maximum efficacious extract was found at the.. Read More»
    DOI: 10.4172/2470-6965.1000S1-002

    Abstract PDF

Relevant Topics

arrow_upward arrow_upward