Cancer Science & Therapy

ISSN: 1948-5956

Open Access

Omar El Mesbahi


  • Case Report
    Reversible Hepatic Cytolysis Secondary to Sunitinib in Metastatic Renal Carcinoma
    Author(s): Omar El Mesbahi and Fatima Zahra El M’rabetOmar El Mesbahi and Fatima Zahra El M’rabet

    Liver damage is further characterized into hepatocellular (predominantly initial Alanine transferase elevation) and cholestatic (initial alkaline phosphatase rise) types. However they are not mutually exclusive and mixed type of injuries are often encountered. Serious drug-induced hepatotoxicity is an infrequent but life-threatening complication often identified through post marketing drug safety surveillance. The main toxicities of Tyrosine Kinase Inhibitors (TKI) therapy are fatigue, rash, diarrhea, hypertension, stomatitis, hand-foot syndrome, hypothyroidism and cardiac toxicity. Whilst most multitargeted TKI exhibit most of the side-effects noted above, each TKI has its particular profile. Sunitinib is an oral multikinase inhibitor that blocks the activity of VEGFR-2 and PDGFR, as well as Src, Abl, insulin-like growth factor receptor-1 and fibroblast growth factor receptor-1 tyros.. Read More»
    DOI: 10.4172/1948-5956.1000056

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