Journal of Metabolic Syndrome

ISSN: 2167-0943

Open Access

Kazuo Watanabe


  • Research Article
    Composite MET-PET Fusion MRI is a Novel Method to Determine Adjuvant Therapy for Growth Hormone Secreting Adenomas
    Author(s): Hidetoshi Ikeda, Yasuhiro Kikuchi and Kazuo WatanabeHidetoshi Ikeda, Yasuhiro Kikuchi and Kazuo Watanabe

    Background: Normalization of abnormal Growth Hormone (GH) and Insulin-like Growth Factor (IGF)-1 secretion is essential for the treatment of acromegaly. Although the diagnostic accuracy of magnetic resonance imaging (MRI) has increased in recent years, MRI may fail to detect residual adenoma, even in patients with high IGF-1 levels. The recently developed composite methionine (MET)-PET fusion 3 Tesla (3T)-MRI technique has helped us to determine the location of adenomas that could not be detected by conventional MRI. Regions with high MET uptake are suggestive of residual adenomas. In this study, we sought to confirm the positional relationship between regions of high MET uptake and the sites of viable residual adenoma cells. Methods: We analyzed the results of six patients who underwent gamma knife radiosurgery or re-operation as adjuvant ther.. Read More»
    DOI: 10.4172/2167-0943.S2-004

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