Journal of Clinical Case Reports

Karel Allegaert

Publications

• Case Report
  Tramadol Disposition in Neonates and Opioid Related Side Effects: The Route of Administration Matters
  Author(s): Karel AllegaertKarel Allegaert
  
  We read the case series of Bilgili et al. on prolonged apnea and sedation in 3 former preterm babies after administration of oral tramadol (2 mg.kg-1) with great interest. Although there may have been additional risks associated with the apnea and sedation events in these specific cases (e.g. low hematocrit, former preterm neonates), we confirm that these side effects were clinically significant and serious. We reported on a similar, unanticipated side effect profile following low dose oral chloral hydrate administration in former preterm neonates for procedural sedation. At least, such observations confirm that prospective studies are urgently needed to improve the effect/side effect balance of analgesic treatment in neonates. Consequently, the authors need to be congratulated for both their effort to perform the study and report the unanticipated side effects. As a neonatologist and.. Read More»
  DOI: 10.4172/2165-7920.1000246

  Abstract PDF