Pulmonary & Respiratory Medicine

Joseph E. Rotsinger

Biography

Adjust blow molding machines, with a great emphasis on spatial orientation, to adjust product weight and dimensions to within specifications needed to meet or exceed own quality control analysis. Sarcoidosis is an idiopathic multisystem disorder characterized by noncaseating epithelioid granulomas predominately affecting lungs and lymph nodes, but with potential to affect any organ system. Sarcoidosis shares similarities in development to other infectious granulomatous diseases, such as berylliosis and tuberculosis; however, its elusive etiology and non-distinctive histology have provided many diagnostic challenges. Evidence of a transferrable antigen combined with a high incidence rate in the lungs has focused efforts primarily on antigens with airborne transmissibility. While Mycobacterium tuberculosis and Propioni bacterium acnes have provided strong associations to implicate each as a contributor to sarcoidosis pathogenesis, detection challenges remain and consensus of a definitive antigen is lacking.

Research Interest

Activation and expansion of sorted T-cells to analyse genetic and protein expression, as well as cytokine secretion, Genomic detection and In-Situ hybridization to localize bacterium in human tissues of multiple diseases, Experimental design of assay used to detect and identify bacterium associated with ventilator associated pneumonia in turn significantly reducing time needed to diagnose, Responsible for Elispot analysis imperative to the enrollment of subjects into a phase 2 clinical trial, Discern and differentiate pathways downstream of cell surface receptors which affect proliferation and provide novel therapeutic targets.