Cancer Science & Therapy

ISSN: 1948-5956

Open Access

Grace Kho Dy

Roswell Park Cancer Institute,
Buffalo, NY

  • Commentary
    Emerging Systemic Therapeutic Approaches for Personalized Medicine in Squamous Cell Carcinoma of the Lung
    Author(s): Grace Kho DyGrace Kho Dy

    During the past decade, a number of novel agents developed for the treatment of advanced NSCLC had, by coincidence, shown survival benefit predominantly among patients with nonsquamous histology, namely pemetrexed (anti-folate), bevacizumab (VEGF pathway inhibition), erlotinib/gefitinib (EGFR receptor tyrosine kinase inhibitors) and crizotinib (ALK receptor tyrosine kinase inhibitor. This has sparked a heightened interest in discovering key molecular aberrations that may be relevant for the treatment of squamous cell carcinoma (SCC) of the lung, a histologic subtype that represents approximately 25% of lung cancer cases diagnosed globally. This article highlights the most promising recent discoveries and targeted agents in development that may be relevant for the treatment of SCC of .. Read More»
    DOI: 10.4172/1948-5956.S11-003

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