Ki 67 as Prognostic Factor in Surgically Resected Pancreatic Ductal Adenocarcinoma
Author(s): Florina-Delia Andriesi-Rusu, Ana-Maria Trofin, Irene Cianga-Spiridon, Nutu Vlad, Alin Vasilescu, Eugen Târcoveanu and Cristian LupașcuFlorina-Delia Andriesi-Rusu, Ana-Maria Trofin, Irene Cianga-Spiridon, Nutu Vlad, Alin Vasilescu, Eugen Târcoveanu and Cristian Lupașcu
Background: Pancreatic ductal adenocarcinoma is one of the most aggressive neoplasms, with a poor prognostic and overall survival, most of the patients (over 80%) being diagnosed in advanced stages of the disease, either with distant metastasis or with the locally unresectable tumor. The Ki-67 antigen is a nuclear antigen expressed in all cellular phases (except for the G0 phase) and a high Ki-67 index can be correlated with a recurrence rate of tumor and survival.Aim: The aim of our study was to demonstrate if the Ki-67 index can be used as a negative prognostic factor for survival.Methods: We reviewed retrospectively all patients with pancreatic ductal adenocarcinoma (confirmed histologically) and were selected only those with resectable tumors (19.5%). For these patients, immunoreactivity fo.. Read More»
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Jan 01, 1970
Accepted Date: Jan 01, 1970
Published Date: Jan 01, 1970