Journal of Clinical Case Reports

Doknic M

Publications

• Case Report
  Giant Prolactinoma Complicated by Cerebrospinal Fluid Rhinorrhea, Behavioral and Neurological Changes Following Dopamine Agonist Therapy: A Case Report
  Author(s): Doknic M, Pekic S, Miljic D, Stojanovic M, Savic D, Gacic-Manojlovic E, Pavlovic D and Petakov MDoknic M, Pekic S, Miljic D, Stojanovic M, Savic D, Gacic-Manojlovic E, Pavlovic D and Petakov M
  
  Introduction: Giant prolactinomas, defined as pituitary PRL-secreting adenomas whose size exceeds 40 mm and with a PRL level of >1000 ng/ml, are very rare. Their treatment and outcome can be unpredictable and challenging for clinicians. Case Report: A 47-year-old male was referred to the Neuroendocrine Department due to a large pituitary tumor invading the suprasellar region, both cavernous and sphenoidal sinuses, and pharyngeal space. He had been suffering from intensive headaches and visual deterioration for two years; he had also experienced sexual dysfunction. Discussion: We detected extremely high serum PRL levels (Ã?â?¹Ã?Æ?700000 mU/l) and hypopituitarism. Bromocriptine therapy (BRC) was started with a gradual dose increase. Ten days after the commencement of medical treatment, cerebrospinal fluid (CSF) rhinorrhea appeared. He underwent neurosurgery two months later; the bone er.. Read More»
  DOI: 10.4172/2165-7920.10001134

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