Department of Orthopedics, Hadassah Hebrew University Medical Center
In her own research, Colleen focuses on the mechanisms of altered lipid and glucose metabolism during obesity and diabetes. She also investigates main causes of liver disease in industrialized countries, namely alcoholic steatohepatitis (ASH), chronic hepatitis C virus (HCV) infection, and nonalcoholic steatohepatitis (NASH). In patients who chronically consume alcohol or are morbidly obese, the progression of liver disease is similar, originating with development of a fatty liver (hepatic steatosis) and then progresses to hepatitis, fibrosis and finally cirrhosis. However, of those patients that develop hepatitis, only a small subset will progress further to cirrhosis. Approximately 20-50% of patients with ASH and ~20% of patients with NASH will progress to cirrhosis suggesting a gene-environment interaction contributes to disease progression.
Journal of Metabolic Syndrome received 48 citations as per Google Scholar report
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