Cancer Science & Therapy

ISSN: 1948-5956

Open Access

Carissa R Moore


  • Review Article
    Targeting TRAF3 Downstream Signaling Pathways in B cell Neoplasms
    Author(s): Carissa R Moore, Shanique KE Edwards and Ping XieCarissa R Moore, Shanique KE Edwards and Ping Xie

    B cell neoplasms comprise >50% of blood cancers. However, many types of B cell malignancies remain incurable. Identification and validation of novel genetic risk factors and oncogenic signaling pathways are imperative for the development of new therapeutic strategies. We and others recently identified TRAF3, a cytoplasmic adaptor protein, as a novel tumor suppressor in B lymphocytes. We found that TRAF3 inactivation results in prolonged survival of mature B cells, which eventually leads to spontaneous development of B lymphomas in mice. Corroborating our findings, TRAF3 deletions and inactivating mutations frequently occur in human B cell chronic lymphocytic leukemia, splenic marginal zone lymphoma, mantle cell lymphoma, multiple myeloma, Waldenström’s macroglobulinemia, and Hodgkin lymphoma. In this context, we have been investigating TRAF3 .. Read More»
    DOI: 10.4172/1948-5956.1000327

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