Virology: Current Research

It is important to develop new antimalarial drugs. Such drugs can target the blood stage of the disease to ease the symptoms, the liver stage to stop deteriorations, and the transmission stage to defend other humans. The tube for the blood stage is flattering healthy, but this should not be a source of satisfaction, as the current treatments set a high standard. Drug discovery labors directed close the liver and transmission phases are in their beginning but are getting increasing care as directing these stages could be contributory in eliminating malaria.

Background: SARS-CoV-2 virus infection poses significant global health challenges and considered a global epidemic sweeping all countries of the world which prompted scientists around the world to search for a quick or safe treatment to preserve people's lives. So far, options for controlling and treating the disease have not been revealed. The current study was conducted to evaluate the effectiveness of pomegranate peels extract against the SARS-CoV-2 virus in the laboratory.

Methods: In this research, two methods of extraction are carried out ethyl alcohol and distal water extract of pomegranate peels. Activity of the extract assessed using 50% Tissue Culture Infectious Doses (TCID50) method in vero E6 cells.

Results: Pomegranate peels extract had the highest inhibitory effect against SARS- CoV-2 virus with IC50 values of 0.125 μl, 0.0625 μl and 0.031256 μl in vero E6 cells.

Conclusion: Based on our results, the aqueous extract of pomegranate peels can inhibit SARS-CoV-2 virus replication in vitro.