Hepatology and Pancreatic Science

This study was performed to quantify the expression of Golgi protein-73 (GP73) in healthy controls and in patients with disease, and to judge the correlations between GP73 and other serum markers in numerous liver diseases. Study the sensitivity and specificity of Golgi Glypican-73 (GP37) as new biomarker useful in early prediction for malignant hepatoma in hepatitis viruses (HBV, HCV) and in chronic liver Cirrhosis; Also in chronic liver diseases. Serum GP73 was measured in 478 healthy controls and 296 patients with differing types of disease. Quantitative hepatitis B virus (HBV) DNA made up our minds in two chronic hepatitis B (CHB) groups. Other serum liver fibrosis markers were measured within the liver fibrosis group and ?-fetoprotein (AFP) was measured in hepatoma (HCC) group. The correlations between GP73 and these markers were evaluated. The GP73 value in hepatitis B- e-antigen (HBeAg)-positive CHB group, HBeAg-negative CHB group, liver fibrosis group and HCC group was significantly higher (p<0.001) than that in healthy controls. GP73 showed significant correlation with other markers within the liver fibrosis group and with AFP within the HCC group. Compared with healthy controls, GP73 in patients with disease was significantly increased. With the progression of disease, GP73 showed a significantly increasing trend. These results suggest that GP73 may be used as a serum marker for the diagnosis of liver diseases and for monitoring disease progression

Background: Upper gastrointestinal bleeding due to peptic ulcer disease is one of the most common emergencies that gastroenterologists encounter. The aim of this study is evaluating the effect of local Tranexamic Acid via endoscopic procedure for control of peptic ulceration bleeding. Materials and Method: during this study, 100 eligible patients with upper GI bleeding thanks to peptic ulcers enrolled and divided to 2 equal groups: within the first group epinephrine injection plus Argon Plasma Coagulation applied as standard treatment (control group), in the second group Tranexamic Acid solution sprayed in addition to standard treatment(intervention group). Estimated blood loss volume, the need of transfusion , hemoglobin drop, vital sign , pulse , got to the second endoscopy, deathrate , got to surgery, admission duration, and drug effectiveness regarding the ulcer location (duodenum or stomach) were evaluated in both groups and the differences expressed statistically. Results: The mean average ages of intervention and control groups were
62.819.6 and 63.117.8, yrs respectively estimated blood loss
and need for transfusion were lower in the intervention group compared with the control group (p-value 0.05) Conclusion: Tranexamic Acid is a useful additive treatment for control of upper gastrointestinal bleeding and can be used in addition to standard treatment

Gastrointestinal disorders represent a number of the foremost frequent complaints during pregnancy possibly due partially to elevated level of progesterone. a number of the foremost common gastrointestinal issue women experience during pregnancy are nausea, vomiting, gallstone, diarrhea and constipation. Pathophysiology -hormonal fluctuations, gastrointestinal motility disorder and psychosocial factors. Symptoms during pregnancy- nausea, vomiting, nausea, tract infection, increased intracranial pressure, appendicitis and hepatitis. Nausea and vomiting may be a common scenario for the ladies during this phase. Nausea with or without vomiting is common in pregnancy. Risk factors for nausea in pregnancy include youth, obesity and smoking. nausea is understood as sickness. Diarrhea- Diarrhea is defined as three or more bowel movements per day. it's usually related to a rise in stool volume (300g/day) Management- metoclopramide will be utilized in pregnancy

Pathological analysis and evaluation of a liver biopsy is a crucial step within the diagnosis of single or multiple mass lesions within the liver. Accurate diagnosis is paramount in guiding appropriate treatment. This study conducted an enquiry for liver biopsies for the past 6 years with the diagnostic search codes of neoplasm, metastases, metastatic, adenocarcinoma, neuroendocrine carcinoma, sarcoma, and lymphoma. The aim was to review their pathological workup with a view to developing cost-efficient immunohistochemical diagnostic algorithms. a complete of 375 consecutive neoplastic liver biopsies were retrieved and subjected to pathological review. for sure the bulk up to 95% of the neoplastic lesions were metastatic lesions. some biopsies up to fifteen represented primary hepatocellular
/cholangiocarcinoma, haemangioma, and cirrhosis. the most typical metastases [upto 61%] to the liver were colorectal in origin being Hepar-ve, CDX2+ve, and CK20+/CK7-ve. Other lesions included metastases from pancreas [12%], lung [8%] upper gastrointestinal [8%], neuroendocrine lesions [8%],
ovarian [1%] and kidney/urothelial [2%]. Uncommon metastases encountered included hepatic metastatic meningioma, endometrial stromal sarcoma, and osteosarcoma. Immunohistochemical stains were the foremost useful test in identifying the first site of the tumor. Though diagnostic algorithms were developed especially within the case of the unknown primary, some biopsies received a medical diagnosis of over one organ because the primary site for clinicopathological correlation.

Obesity is up to about 5% of cases the matter of education
and not medicine. For an efficient intervention is important
within the first place timely identify its initial stages and
simultaneously identify the variables that may affect by the
external interventions. this epidemic of obesity could be a
problem not only public health, but each individual. the
fundamental tool for successful intervention is to vary the
approach to life from sedentary to active of intervened
individuals. the primary step is early diagnostics and so
selecting individual approach that respects the health,
previous experience physical, good shape, time and
economic conditions and also the relationship with its
surroundings to influence obesity of the topic. Physical activity
is now admitted as being an integral element of adult obesity
treatment, but it's not clear which intervention is that the most
effective. Physical activity is an especially complex behavior
that needs active involvement of the themes and his nearly
environment furthermore. it's influenced by personal, family
and environmental factors and every of those elements will be
a possible barrier in preventing active participation of the
topic, therefore compromising a successful implementation of
a program. These limitations are obvious for moderate-tovigorous
physical activity which is sometimes recommended
for treating obese persons.