This review delves into the intriguing relationship between Adverse Childhood Experiences (ACEs) and the risk of developing Multiple Sclerosis (MS). While extensive research has connected early life adversity to various health outcomes, the potential mechanisms linking ACEs to MS development remain underexplored. This review synthesizes existing literature to elucidate plausible pathways, including immunological, neurobiological and psychosocial factors. Understanding these mechanisms is essential for developing targeted interventions and preventive strategies to mitigate the impact of ACEs on MS susceptibility. This comprehensive review navigates the intricate connections between Adverse Childhood Experiences (ACEs) and the heightened risk of developing Multiple Sclerosis (MS). As our understanding of autoimmune disorders continues to evolve, the synthesis of existing literature underscores the complex interplay of neuroimmunological, psychoneuroimmunological and psychosocial mechanisms linking ACEs to MS susceptibility. Recognizing the potential vulnerabilities induced by early life adversity provides a foundation for targeted interventions and preventative measures.
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Journal of Trauma & Treatment received 1048 citations as per Google Scholar report
