Journal of Trauma & Treatment

ISSN: 2167-1222

Open Access

The Efficacy of Surgicel Compared with Simple Gauze Packing in Grade IV Liver Laceration; A New Hope for Trauma Patients: An Experimental Study


Hadi Khoshmohabat, Alireza Makarem, Mohammad Yasin Karami, Hamid Reza Rasouli, Zahra Danial, Golnoosh Mahmoodizade, Rohallah Rezaei, Shahram Paydar, Seyede Niloofar Dastgheib, Seyed Ali Hossein Zahraei and Zahra Shayan

Background: The useful surgical hemostasis agent using in patients with grade 4 of the liver laceration is a challenging problem. This study assessed a topical hemostatic agent (Surgicel) using a partial hepatic laceration hemorrhage model. This experimental study compared the hemostatic effects of Surgicel and conventional gauze packing in hepatic parenchymal bleedings.

Methods: Twenty male Wistar albino rats (weight 250 ± 50 g) were randomly divided into two groups. Within each treatment group, surgicel or gauze packing (GP) (n=10/group) was applied to the liver laceration site that was created in the large lobe of the liver.

Results: There was statistically significant difference between two groups regarding the changes of before and after operation of HCO3 (P=0.019). Across two groups, rats receiving surgicel lost less blood and formed clots more frequently than GP (p<0.001).

Conclusion: Surgicel may be useful to treat hemorrhage from Liver lacerations in trauma patients.


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