Chandana Ullas and Nandini Manoli
Breast cancer is the most common cancer in urban Indian women with age adjusted rate of 25.8 and mortality of 12.7 per 1,00,000 women. Prognosis is
greatly determined by clinicopathological and molecular characteristics of the tumor. Hormone receptor status evaluation has become a critical determinant for
classification and management of breast cancer. Estrogen receptor (ER) status has emerged as important criteria in determining the prognosis and treatment as
it plays a major role in tumor metastasis.
Aim of this study is to assess the relationship between morphological features and hormone receptor status of invasive breast carcinoma. This is a retrospective
study of 25 cases of breast carcinoma diagnosed between July2020-December2020 in the department of pathology, JSS Medical college, Mysore. The tumors
were categorized into ER+PR+ (36%), ER+PR-(20%), ER-PR+ (0%), ER-PR-(44%). Well differentiated low grade invasive carcinomas were frequently ER+PR+
whereas high grade infiltrating carcinomas were mainly ER-PR-. Tumor necrosis, lymphovascular invasion, lymph node involvement, high tumor grade were more
frequently associated with ER-PR- status. Histopathological evaluation and grading of breast cancer substantiated by hormone receptor status forms a reliable
tool in determining treatment modality and prognosis of the patient.
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Journal of Oncology Translational Research received 93 citations as per Google Scholar report
