Journal of Molecular Biomarkers & Diagnosis

ISSN: 2155-9929

Open Access

Significance of Macrophage Migration Inhibitory Factor (MIF) and Anti P 53 Antibodies in Prognosis of Hepatocellular Carcinoma


Lamiss Mohamed Abd Elaziz Sad, Samar Galal Younis and Hala Mohamed Nagi

Background and aim: Prognosis of hepatocellular carcinoma (HCC) is very poor and determining the prognosis rely many factors and we aim at defining the prognostic factor of macrophage migration inhibitory factor (MIF) , anti P53 and its correlation with other prognostic factors in HCC.

Patients: Serum macrophage migration inhibitory factor and anti-p53 antibodies were measured in139 patients diagnosed with HCC using a specific enzyme-linked immunosorbent assay (ELISA) kit. The clinicopathological characteristics of the patients were compared with respect to the presence of serum anti-p53 antibodies.

Results: In univariate analysis, the prognostic factors of overall survival with statistical significance were portal vein thrombosis, total serum bilirubin, serum albumin, serum AST, serum ALT, Prothrombin time, viral marker and anti p53 antibody and MIF and on multivariate analysis the prognostic factors were BCLC staging, presence of extrahepatic metastases, the patient received treatment or not, anti p53 antibody and MIF.

Conclusion: Both MIF and Anti p53 antibody are associated with poor prognosis in HCC and it increased the prognostic potential of alpha fetoprotein.


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