Highly proliferative, diverse cells that are proliferating inside an adaptable, changing tumour microenvironment make up cancer. As a result of decades of cancer research, cancer survival rates have greatly increased. The difficulties of simulating the complexity and multicellular foundation of human disease, however, are reflected in the fact that many experimental and preclinical research do not translate to the bedside. Organoids are brand-new, intricate, three-dimensional tissue cultures that are produced from tissue-resident progenitor cells, induced pluripotent stem cells, or embryonic stem cells. They serve as a close approximation to a physiological model for the study of cancer. Organoids can accurately represent the various genetic, molecular, and pathophysiological characteristics of cancer since they self-organize during development. Additionally, these organoids' relevance in cancer research has expanded thanks to co-culture techniques and the capacity for genetic manipulation.
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Journal of Tissue Science and Engineering received 807 citations as per Google Scholar report
