Leukotriene receptor antagonist (LTRA) montelukast is frequently used for breathing difficulties associated with sleep, allergic rhinitis, and asthma. Recent investigations have documented a number of negative outcomes in kids, including neuropsychiatric problems and sleep difficulties. Objective: To learn more about the safety profile of montelukast for kids with allergies, hay fever, and breathing problems related to sleep. Method and findings: Over a two-year period, we retrospectively examined all adverse medication reactions to montelukast among 385 kids aged 6 months and older in six tertiary centres. 89.6% of patients had asthma, 50% had allergic rhinitis, and 13.6% had breathing problems linked to sleep. Singulair was the most widely used form of montelukast, accounting for 67.9% of all prescriptions. According to this study, there were 123 individuals who experienced adverse medication responses, and the majority of them were in those toddlers (22.8%) and those between the ages of 4 and 9 (52.8%) were the next two age groups. 9.8% of the children had two (ADRs) documented, whereas 5.5% had three or more. The most frequent adverse drug reactions (ADRs), which affected 15.1% of participants (overlap was widespread; 5.5% of kids had trouble sleeping, 4.4% had trouble falling asleep or staying asleep, and 1.82% had nightmares), were agitation (10.4%), pain (9.4%), and hyperactivity (6.8%).
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Journal of Lung Diseases & Treatment received 247 citations as per Google Scholar report
