Journal of Pediatric Neurology and Medicine

ISSN: 2472-100X

Open Access

Long-term Neuropsychological Outcome and Quality of Life in Perinatal Ischemic Stroke


Agnese Suppiej, Annalisa Traverso, Laura Baggio, Ambra Cappellari, Paolo Simioni, Mario Ermani, Stefano Sartori and Elisa Cainelli

Background: Perinatal arterial ischemic stroke is an established risk factor for neuromotor and cognitive sequelae, but little is known about long-term neuropsychological implications. We aimed to evaluate long-term neuropsychological outcome and its effect on life quality in children with history of perinatal arterial ischemic stroke.

Methods: Seventeen children with history of perinatal arterial ischemic stroke, selected from the institutional cerebrovascular registry, were recruited for this study. Outcome was investigated using a battery of standardized neuropsychological tests and PedsQL questionnaire. A neuropsychological composite score (Cognitive Index) was calculated taking into account impaired performances.

Results: 47% of the patients had impaired Cognitive Index. Neuropsychological functions involved included: language, visuo-motor and executive functions, visual selective attention, with sustained attention as the most affected (59% of patients). Impairment in Cognitive Index was significantly associated with poor quality of life as perceived by parents.

Conclusion: In conclusion, minor impairments, such as neuropsychological deficits, can frequently occur in children with history of perinatal arterial ischemic stroke and may affect quality of life.


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