Journal of Nephrology & Therapeutics

ISSN: 2161-0959

Open Access

IgA Nephropathy, β Thalassemia Minor, Psychosis and Deafness: A New Syndrome?


Sanda Mrabet *,Latifa Bourkhis ,Soumaya Ben Abdelkarim ,Awatef Azzabi ,Dorsaf Zellama ,Safa Nouira ,Wissal Sahtout ,Yosra Guedri ,Moncef Mokni ,Abdellatif Achour

A 43-year-old male was admitted to our hospital because of renal failure and arterial hypertension. He was followed from the age of 15 years for psychosis and had no familial history of disease. Investigations revealed sensorineural deafness, a microcytic hypochromic anemia with normal ferritin leading to the diagnosis of β thalassemia minor and nephrotic syndrome. Examination of the renal biopsy specimen demonstrated severe Ig A nephropathy. No classic cause of IgA nephropathy was found. Review of literature showed two previous reported cases of Ig A nephropathy associated with β thalassemia minor but without deafness or psychosis. We wonder through this case if an explanation to this association may be made by a genetic defect.


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