Md S Islam and Abdul Aziz NM
This project is developed because patients have modest taste expectations for drug product-they need to be palatable. Palatable drug products generally have moderate attributes – not too bitter, hard, gritty, chalky or irritating. Taste masking of drug by coating of granules preparations of oro-dispersible tablet in-vivo study of taste and in-vitro drug release study is enhance rapid bioavailability and rapid onset of action, improve patient comfort and compliance. Tiemonium methylsulfate prevents the effects of acetylcholine by blocking its binding to muscarinic cholinergic receptors at neuroeffector sites on smooth muscle of GI tract 2 but it is a very bitter drug and slightly soluble in water. So the objective of the present work is to formulate dispersible or orodispersible tablets of this highly bitter drug, where in which its bitter taste is masked. Several techniques are available for the design of taste masking dosage forms as indicated in the introduction chapter. In the present study, the taste masking is done by using ion exchange resin complexation technique. It was preferred over other taste masking methods, as the drug releases occur only in the acidic environment without being released in saliva where by the bitterness of the drug get taste masked. All pre-formulation data compiled the idea property of taste masking oro-dispersible property of tablet. All formulations disintegrate within 60 sec and drug dissolution data showed that all formulation gives around 90% drug release within 120 seconds. Finally we can conclude that this experimental work may be a good way for the development of taste masking and oro-dispersible tablet.
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Pharmaceutical Regulatory Affairs: Open Access received 533 citations as per Google Scholar report
