Bioceramics Development and Applications

ISSN: 2090-5025

Open Access

Effect of Copper and Zinc on the Bioactivity and Cells Viability of Bioactive Glasses


Wers E, Bunetel L, Oudadesse H, Lefeuvre B, Lucas-Girot A, Mostafa A and Pellen P

Bioactive glasses, doped with traces of copper (Cu) and zinc (Zn) were synthesized by fusion method. Cu and Zn present interesting functions for the biological metabolism through their antibacterial, anti-inflammatory and antifungal properties. Several physical methods were employed to characterize the bioactive glasses before and after immersion in a Simulated Body Fluid (SBF). The “in vitro” experiments showed that after soaking in SBF, the behavior of bioactive doped glasses are different compared to pure glass 46S6. Obtained results show that glass matrix undergoes some changes after 15 days of immersion. The non toxic character of doped glasses was confirmed after 24 hours of incubation. The kinetic of release of Cu and Zn was carried out. It highlights that Cu is more released than Zn. By SEM, the morphology of hydroxyapatite obtained with Zn-doped glass show a better crystallization compared to Cu-doped glass.


Share this article

Google Scholar citation report
Citations: 926

Bioceramics Development and Applications received 926 citations as per Google Scholar report

Indexed In

arrow_upward arrow_upward