Journal of Cytology & Histology

Diffuse Parenchymal Lung Disease-Diagnostic Approach by Radiology and Histopathology

Abstract

Aastha Gupta, Shaista M Vasenwala, Kafil Akhtar, Rakesh Bhargava, Ibne Ahmad and Veena Maheshwari

Aims and objective:This study aims at evaluating the patients of diffuse parenchymal lung disease (DPLD), by comparing radiological and cyto-histopathological findings to determine the importance of histopathology in the diagnosis of DPLD.

Materials and methods:Seventy patients with chief complaints of dyspnoea & cough and bilateral diffuse shadows on chest radiography were selected. High resolution computed tomography (HRCT) and bronchoscopy was done for further assessment.

Results:Out of70 patients, 44 were finally diagnosed on the basis of bronchoscopic findings, as usual interstitial pneumonia (UIP) 24 cases (54.5%) and as non UIP in 20 cases (45.5%). Two cases of UIP additionally suffered from bronchogenic carcinoma.

Conclusion:A combination of clinical, radiological, cytological and histological findings is necessary to evaluate the cases of DPLD and transbronchial needle biopsy (TBNB) gives a definitive edge over other diagnostic measures.