Epilepsy, a neurological disorder characterized by recurrent seizures, often coexists with cognitive dysfunction. While structural brain abnormalities detected by Magnetic Resonance Imaging (MRI) are commonly associated with cognitive impairments in epilepsy, a subgroup of individuals presents a puzzling scenario-normal MRI findings in the presence of cognitive dysfunction. This article explores the intriguing phenomenon of cognitive impairment in epilepsy with normal MRI results. Various hypotheses, including microstructural changes, functional connectivity alterations, and neuroinflammation, are discussed to elucidate the underlying mechanisms. Clinically, a comprehensive assessment, individualized treatment, and regular monitoring are essential for addressing cognitive dysfunction in these cases. A deeper understanding of this paradox may lead to improved strategies for managing cognitive dysfunction in epilepsy, regardless of MRI outcomes.
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Epilepsy Journal received 41 citations as per Google Scholar report
