Journal of Pediatric Neurology and Medicine

An infantile spasm (IS) is a subset of epileptic syndromes that occur almost exclusively between 3 months and 1 year of age. Children are present with clusters of sudden, symmetric spasms. Due to the large number of associated conditions and syndromes that are known to present with IS, a unique, causal mechanism at the core of IS remains elusive. Current first-line therapies include ACTH, corticosteroids, and vigabatrin; however, the inconsistent and unpredictable efficacy of treatment warrants a closer look into novel approaches in research that seeks to better understand the diverse ways in which IS can develop. In this report, we investigate the medical course of a 9-month-old female who was born at 34-weeks gestation with known prenatal brain insult who presents with concomitant complex partial seizures and infantile spasms.