Journal of Bioanalysis & Biomedicine

ISSN: 1948-593X

Open Access

Anti-Hyperglycemic and Antioxidant Effect of Saraca asoca (Roxb. De Wilde) Flowers in Streptozotocin-Nicotinamide Induced Diabetic Rats: A Therapeutic Study


Shanti Bhushan Mishra and Vijayakumar M

50% Ethanolic extract of Saraca asoca Roxb. de Wilde flowers (SAE) was screened for its antihyperglycemic and antioxidant effect in streptozotocin-nicotinamide induced diabetic rats. Phytochemical analysis of SAE revealed the presence of phenolic compounds phytosterol, flavonoids and saponins. After the administration of extract 200 mg/kg body weight/day) in diabetic rats has improved the elevated levels of blood glucose (p<0.01). The decreased activities of key antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione in diabetic rats were brought back to near normal range upon SAE treatment. Our studies demonstrate the anti-hyperglycemic and anti-oxidative potential of Saraca asoca which could exert sympathetic effects against the diabetes and associated free radicals complications.


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