Starvation Therapy for Cancer: Current Knowledge, Guidelines and Research Prospects

5^th World Congress on Cancer Therapy

September 28-30, 2015 Atlanta, USA

Fawwaz Shakir Al Joudi

The Industrial Park, Puchong, Malaysia

Posters-Accepted Abstracts: J Cancer Sci Ther

Abstract :

Cancer is a serious disease that has used exhaustive efforts, and exerted heavy financial and scientific burdens to develop an understanding into the nature of its� various types, and to advance therapies and management protocols. It is becoming acceptable that among the major methods that appeared in the literature has been the use of starvation to reduce or even halt the survival of cancer cells at the time when normal cells would be less dramatically affected. Hence this review represents a comprehensive display of the effects of starvation on cells, the effecter mechanisms of starvation on various cells, and the definite experimental and clinical information available on this topic. These experiences are aimed at understanding and developing suitable and effective methods based on nutritional manipulations, for combating malignancies. Starvation modules generally include energy or glucose deprivation under normal or abnormal oxygenation, amino acid and nucleic acid deprivation, and other selected nutritional precursors. There are also experiments to study the effects of combined deficiencies. In addition, these artificial nutritional deficiencies have been tested for their potential uses in boosting the effects of chemotherapeutic agents. Nevertheless, negative effects of certain nutritional starvation modes have also been described extensively along with much of their underlying cellular mechanisms. Knowledge of these may give leads as to what methods to avoid among the available choices. They also serve as guidelines for research into developing methods for antagonizing or neutralizing such unanticipated negative effects.

Biography :

Email: fawwazaljoudi@gmail.com