PREPARATION AND EVALUATION OF MICROSPHERES OF NATURAL GUMS CONTAININGAN ANTI-VIRAL DRUG

27^th International Congress on Pharmaceutical Biotechnology Research

June 23-24, 2025 Webinar

Bhavana K, Ekshitha G, Rajkiran K

Department of Pharmaceutics, Sri Sivani College of Pharmacy, Indiabhavanapharma56

Scientific Tracks Abstracts: Pharm Regul Aff

Abstract :

WebinarAbstractThe current study concern with the preparation and evaluation of microspheres of naturally occurring gums in the view ofeffectiveness, biodegradable, easy of availability, cost effectiveness with Lamivudine as model drug. Lamivudine is an activeanti-retroviral drug having biological half life of 4-6 hours and 86% bioavailability and licensed for the treatment of HIVand chronic Hepatitis B. Microspheres of Lamuvidine were prepared using xanthan gum and guar gum by solventevaporation technique. Compatibility study was carried out by using FTIR at the range of 4000 to 400 cm-1 shows nosignificant change in the characteristic peaks of Lamuvidine and excipients in all the formulation, which indicates thecompatibility of Lamuvidine with excipients. The prepared microspheres were analyzed for particle size, surfacemorphology, % yield, % drug entrapment efficiency, in-vitro drug release studies, in-vitro drug release kinetics and stabilitystudies. Microspheres thus obtained were found to be pale yellow color and free flowing. Micromeritic studies of theprepared formulations are found within the prescribed limits and indicated good flow property. The Scanning ElectronMicroscopy (SEM) studies inferred the spherical shape and size range of 100μm to 200μm. In-vitro drug release showsdecreases as concentration of xanthan gum increases. The release kinetics study revealed that the prepared microsphereswere best fitted to the zero order and indicates that drug release from microspheres was diffusion-controlled and that themicrospheres were stable. We conclude that, microspheres offer a practical and suitable approach to prepare controlledrelease of Lamuvidine with natural occurring xanthan gum as rate controlling agent to enhance bioavailability andreduction in dose frequency.Keywords: Lamivudine; Xanthan gum; microspheres; Solvent evaporation; and oral controlled drug delivery.

Biography :

K.Bhavana has her own experience in valuation and passion for ML and data. The research team built this model after many years ofexperience in research, evaluation, work in both hospitals and scientific laboratories. This approach meets all the requirements forprecise, specific, sensitive diagnostics.