Inosine 5’-monophosphate dehydrogenase (IMPDH) as an anticancer target: Renewed interest and recent progress

9^th Indo Global Summit on Cancer Therapy

November 02-04, 2015 Hyderabad, India

Prashant S Kharkar

NMIMS Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, India

Posters-Accepted Abstracts: J Cancer Sci Ther

Abstract :

IMPDH is an enzyme required for the de novo synthesis of guanine nucleotides. IMPDH inhibitors have found their usefulness as anticancer, antiviral, immunosuppressive, antimicrobial agents, etc. Despite being an old target, there is renewed interest in IMPDH inhibitors as anticancer agents. Several classes of inhibitors have been reported as anticancer agents. The talk will summarize the molecular details of IMPDH as a target and the recent progress made in the design and development of IMPDH inhibitors as anticancer agents, with particular emphasis on the computer-aided molecular design of the inhibitors.

Biography :

Email: Prashant.Kharkar@nmims.edu