Design, synthesis and antiproliferative activity of 6-substituted Pyridazin- 3(2H)-ones

5^th World Congress on Cancer Therapy

September 28-30, 2015 Atlanta, USA

Mohamed Elagawany1 and Mohamed A Ibrahim2,3

1Damanhour University, Egypt
2Organic Chemistry Department, College of Pharmacy, Misr University for Science and Technology, Al- Motamayez District, Egypt.
3Department of Pharmaceutical Chemistry, College of Pharmacy, Almaarefa Colleges f

Scientific Tracks Abstracts: J Cancer Sci Ther

Abstract :

Cancer is not just one disease, but a generic term used to encompass a group of more than two hundred diseases sharing common characteristics. Among all diseases that affect humanity, cancer ranks high as a major killer. Although major advances have been made in the chemotherapeutic management of some patients, the continued commitment to the arduous task of discovering new anticancer agents remains critically important. The discovery that several novel series of 3(2H)- pyridazinones possess characteristic pharmacological and biological activities stimulated great interest in pyridazine chemistry, which continues to this day. In this work the design and synthesis of 6-substituted pyridazinone derivatives are described. Antiproliferative screening revealed that novel compounds have modest activity against MCF-7 â�?�?breast cancer cell lineâ�?. SAR analysis and docking calculations were carried out to aid in the interpretation of the results. Taken together, our findings suggest that 6-substituted pyridazinone scaffolds are interesting starting points for design of novel potent anticancer drugs.

Biography :

Email: alfath_tours@yahoo.com