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Stem Cells Review Articles | Open Access Journals
Journal of Phylogenetics & Evolutionary Biology

Journal of Phylogenetics & Evolutionary Biology

ISSN: 2329-9002

Open Access

Stem Cells Review Articles

In separated cells, the essential jobs of the p53/TP53/Trp53 translation factor and tumor silencer are managing cell cycle capture, cell senescence, and cell demise in light of DNA harm and other cell stresses. p53 works basically through transcriptional initiation of the cyclin‐dependent kinase inhibitor p21/CDKN1A to keep cells from entering S‐phase, and the proapoptotic proteins PUMA/BBC3 and NOXA/PMAIP1  to actuate the fast enlistment of apoptosis when the impacts of cell stress are too incredible to possibly be turned around. In any case, separation, improvement, and maturing require p53 levels to be absolutely controlled in a spatial and transient way  that starts with p53‐dependent translation in the blastocyst  and proceeds with p53‐dependent epigenetic changes during early stage advancement Incomprehensibly, p53 is required to keep up genomic security in grown-ups yet it isn't fundamental for early stage advancement

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Citations: 911

Journal of Phylogenetics & Evolutionary Biology received 911 citations as per Google Scholar report

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