Insulin resistance, hyperinsulinemia, and products associated with insulin metabolism can affect the amyloid cascade and promote the onset of Alzheimer`s disease or aggravate the condition, in early or old age regardless of the development of type 2 diabetes. The changes described in pathological studies and molecular research, classify two types of the mechanism involved with cognitive impairment in these cases: one related to cerebrovascular events due to the action of vascular risk factors, and the other more controversial, a non-cerebrovascular mechanism involving the interaction of insulin with Aβ in the entorhinal cortex and hippocampus, as well as its synaptogenesis action that involves signaling of intracellular molecular paths in the modulating of neurotransmitters such as acetylcholine, norepinephrine and glutamate receptors. Based on a literature review, the role of insulin in the Central Nervous System is examined along with its participation in the amyloidogenesis process in progression to Alzheimer's Disease. A journal could also be a periodical publication intended to further progress of science, usually by reporting new research. Most journals are highly specialized, although variety of the oldest journals publish articles, reviews, editorials, short communications, letters, and scientific papers across an honest range of scientific fields. Journals contain articles that peer-reviewed, in an effort to make sure that articles meet the journal's standards of quality and scientific validity. Each such journal article becomes a neighborhood of the permanent scientific record.
Editor’s Note: Journal of Diabetic Complications & Medicine
Editor’s Note: Journal of Diabetic Complications & Medicine
2021 Conference Announcement: Journal of Diabetic Complications & Medicine
2021 Conference Announcement: Journal of Diabetic Complications & Medicine
Editor Note: Journal of Diabetic Complications & Medicine
Editor Note: Journal of Diabetic Complications & Medicine
Research Article: Journal of Diabetic Complications & Medicine
Research Article: Journal of Diabetic Complications & Medicine
Review Article: Journal of Diabetic Complications & Medicine
Review Article: Journal of Diabetic Complications & Medicine
Posters & Accepted Abstracts: Cancer Science & Therapy
Posters & Accepted Abstracts: Cancer Science & Therapy
Posters & Accepted Abstracts: Cancer Science & Therapy
Posters & Accepted Abstracts: Cancer Science & Therapy
Scientific Tracks Abstracts: Pulmonary & Respiratory Medicine
Scientific Tracks Abstracts: Pulmonary & Respiratory Medicine
Posters & Accepted Abstracts: Journal of Nephrology & Therapeutics
Posters & Accepted Abstracts: Journal of Nephrology & Therapeutics
Journal of Diabetic Complications & Medicine received 102 citations as per Google Scholar report
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