Journal of Oncology Medicine & Practice

Department of Chemistry, University of Chicago, Chicago, USA

Publications

• Mini Review   
  Heterochromatin Protein 1α: A Characteristic of Cell Proliferation That is Pertinent to Clinical Oncology
  Author(s): Wenbin Lin*
  
  Heterochromatin Protein 1α (HP1α) is a critical player in chromatin organization and gene regulation, and its dysregulation has been implicated in various cellular processes, including cell proliferation and cancer development. This review focuses on the role of HP1α as a characteristic of cell proliferation that is pertinent to clinical oncology. Extensive research has demonstrated that HP1α plays a dual role in regulating cell proliferation. On one hand, it functions as a transcriptional repressor, modulating the expression of genes involved in cell cycle control and DNA replication. On the other hand, HP1α has also been found to interact with numerous signaling pathways and transcription factors, thereby promoting cell proliferation under certain conditions. Aberrant expression and localization of HP1α have been observed in va.. Read More»
  DOI: 10.37421/2576-3857.2023.08.199

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