Journal of Clinical Case Reports

Neurology Unit, Stroke Unit, Gubbio-Gualdo Tadino and Città di Castello Hospitals, USL Umbria 1, Italy

Publications

• Case Report   
  Neuroleptic Malignant Syndrome Due to Donepezil
  Author(s): Manuel Monti*, Francesco Paciullo, Paolo Diego L’Angiocola, Silvia Cenciarelli and David Giannadrea
  
  Neuroleptic Malignant Syndrome (NMS) first described nearly five decades ago, is an idiosyncratic, life-threatening complication of treatment with drugs that is characterized by fever, sever e muscle rigidity, and autonomic and mental status changes. There are many different drugs that can cause NMS. Most of the drugs are antipsychotic drugs. NMS can also develop when dopaminergic drugs are suddenly withdrawn, but there are also other drugs that don't belong to any of the above categories. An old male patient was admitted to our Emergency Department for intermittent fever with onset from three days. His medications included amlodipine, oral steroid, and donepezil, which was administered at the dose of 10 mg/day. At the time of admission the patient showed stupor without other relevant signs at the physical exam. Infectious diseases and systemic diseases were ruled out during the cours.. Read More»
  DOI: 10.37421/2165-7920.2020.10.1378

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