Journal of Clinical Case Reports

Department of Neurosurgery, Nara Medical University, Nara, Japan

Publications

• Case Report   
  A Case of Craniopharyngioma with Malignant Transformation after not Radiation Therapy but Growth Hormone Replacement Therapy
  Author(s): Fumihiko Nishimura*, Miho Kakutani, Young-Soo Park, Yasushi Motoyama, Ichiro Nakagawa, Shuichi Yamada, Kentaro Tamura, Ryosuke Matsuda, Yasuhiro Takeshima, Yoshiaki Takamura and Hiroyuki Nakase
  
  Background: We present a rare case of malignant transformation of a craniopharyngioma in a patient who received growth hormone replacement therapy. Case description: A 43-year-old male came to our department with a headache and visual disturbance and was admitted. Brain Magnetic Resonance Imaging (MRI) revealed a giant tumor in the intra- and suprasellar region compressing the optic chiasma. Using a transcranial pterional approach the tumor removal was performed as much as possible with the residual mass removed later with a trans-sphenoidal approach. The initial histopathological diagnosis was adamantinomatous craniopharyngioma. Decompression of the optic chiasma was achieved and visual function improved though residual tumor tissue remained in the parasellar region without regrowth seen for more than 24 years. At the age of 67 years the pa.. Read More»
  DOI: 10.37421/2165-7920.2023.13.1579

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