Journal of Phylogenetics & Evolutionary Biology

ISSN: 2329-9002

Open Access

Dan Xie


  • Review Article
    Studies of Natural Selection in the Era of Next-generation Sequencing

    Author(s): Momiao Xiong, Dan Xie, Pengfei Hu and Zheng HouMomiao Xiong, Dan Xie, Pengfei Hu and Zheng Hou

    A deeper understanding of positive selection is of fundamental importance. Evolutionary pressures acting on the genome as a whole and the specific role of environmental pressures on divergence shape the natural selection. However, despite the intense interest in genome-wide scans, a coherent study of recent human evolutionary history has yet to emerge due to the limitations of data, models, and analytical tools. Fast and cheaper Next Generation Sequencing (NGS) technologies will generate unprecedentedly massive and highly-dimensional genomic variation data. NGS will offer unprecedented opportunities for population genetic and natural selection studies, but also raise great challenges. In the conventional population genetics, most researches have primarily focused on natural selection acting on a single locus. Little attention has been paid to determining how the natural selection acts.. Read More»
    DOI: 10.4172/2329-9002.1000104


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