Journal of Clinical Case Reports

Use of Liposomal Amphotericin B in Kala-Azar

Abstract

Tanjir Rashid Soron

We report a case of 23-year old male from Tangail who developed intermittent fever and blackening of skin 7 months back. He was locally diagnosed as a case of kala-azar and was treated with Cap Miltefosine 50 mg 12 hourly for 28 days. But within 4 months after completing the treatment he again developed the symptoms. Referred from the local hospital he presented to us with fever, weight loss and discoloration of skin. He was anemic and had splenomegaly. Laboratory investigations showed pancytopenia, elevated Erythrocyte Sedimentation Rate (ESR). Leishman-Donovan body was found inbone marrow biopsy. In our hospital he was treated with injection Liposomal Amphotericin B 15 mg/kg in 6 divided doses. His anemia was corrected, spleen size became normal and bone marrow aspiration showed no Leishman-Donovan body on discharge and he remained symptoms free in the outpatient department.