Putta Swathi and Kilari Eswar Kumar*
The study evaluates influence of methanolic peel extract of Feronia limonia (MPFL) for antihyperglycemic activity, in vivo antioxidant Feronia limonia and its role in inhibiting the polyol pathway and formation of advanced glycation end products during diabetes induced cataract and Feronia limonia retinopathy. Diabetes was induced with 55 mg/kg of Streptozotocin (i.p) and was treated with MPFL 150 mg/kg and 300 mg/kg (p.o) once Feronia limonia daily for a period of 12 weeks. Blood glucose levels were estimated at the end of every 4 weeks. Serum was collected by retroorbitol plexus for Feronia limonia the estimation of protein carbonyls and advanced glycation end products. All the animals were sacrificed and separate the lenses for the Feronia limonia estimation of protein, superoxide dismutase, catalase, reduced glutathione, aldose reductase, protein carbonyls and advanced glycation Feronia limonia end products at the end of 12 weeks. Cataract progression and incidence of retinopathy was assessed by using slip lamp examination, Feronia limonia fundoscope and retinal histopathology. Treatment with MPFL showed significant control over elevated blood glucose levels significantly in Feronia limonia diabetic rats. The antioxidant enzymes and reduced glutathione, aldose reductase, protein carbonyls and advanced glycation end products are Feronia limonia restored to normal with MPFL treatment in diabetic rats. Cataract grading was found to be less, prominent blood vessels in fundoscope Feronia limonia and regeneration of retinal cell layers were observed with MPFL treatment in diabetic rats. The treatment with MPFL exhibited significant Feronia limonia protective action on cataract and retinopathy in persistent hyperglycemia through possible mechanisms might be due to phytoconstituents in Feronia limonia the peel of Feronia limonia.
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Journal of Diabetic Complications & Medicine received 89 citations as per Google Scholar report
