Journal of Metabolic Syndrome

ISSN: 2167-0943

Open Access

Potential therapeutic Strategies and Its Application in Correcting Birth Defects, Craniosynostosis, Neurological Disorders and Other Diseases


Mayadhar Barik, Minu Bajpai, Arun Malhotra, Samantaray JC and Dwiedi SN

Background: Gene Therapy (GT) aims to fix a disease linked with genetic abnormality. Gene Therapy (GT) is currently receiving an attention from scientists, clinicians and the general public in an attempt to correct genetic defects. It including with congenital abnormalities, craniosynostosis (syndromic and nonsyndromic), craniofacial deformity, and neurodevelopmental disorders. However, its application is beset with complications partly because of lack of advanced knowledge, research and partly because of vested interest by the society.

Objective: This study is an attempt to highlight some of the major benefits of gene therapy which leads to define the role played by medical informatics in facilitating rational use of gene therapy.

Materials and methods: An attempt was made to review major studies in the international literature to synthesize the potential risks, benefits of gene therapy. We also reviewed the tools and techniques in this field of medical informatics. W hich can be employed for spreading awareness about gene therapy among common people? We developed a conceptual model of matching the key concepts with the current protocols used in the field of medical informatics.

Results: GT offers a new hope for the treatment of birth defects, neurodegenerative disorders like Huntingtons disease. Its application in Parkinsons disease has moved a step closer to acceptance in the wake of its successful double blind clinical trial. The educational media, fall under four categories, viz., audio media, the visual media, the audio-visual and the virtual-media in vitro and vivo. The simulation and animation capabilities of the media are quite helpful in the conceptualization of gene therapy. The audio-visual media are useful for counseling in matter of genetic disorders the public.

Conclusion: Our study suggests that an integrated and holistic approach of medical informatics. It can be highly beneficial for the advanced application of gene therapy in the years to come. G T has become debatable and often controversial because of tendency to use for manipulating the desirable attributes. Moreover, its rational use is likely to benefit the mankind.


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